Scupltra™ is a poly-L-lactic acid (PLLA) containing filler which is considered “semi-permanent” due to its longevity in tissues (2 years or more). It is primarily used to improve a generalized loss of subcutaneous fat which results in thin skin and sallow appearance to the face. It is commonly used in conjunction with other fillers which can be used to treat specific grooves or lines. The treatment usually consists of three injection sessions over a 3 month period (one month apart). Patients begin to see a change usually by the second session. Ice is used as the topical “anesthetic” although larger treatment areas can be anesthetized with topical cream and local injection if the patient desires. Post injection bruising and swelling can occur although most people are able to get back to their normal activities immediately. No deep rubbing the injected areas and no exercise or flying for 24 hours. In general, these agents are very safe and usually act locally where they are injected, systemic effects are rare.